Aside from smaller crashes I've had in the desert, I've had several pretty good crashes at speed on the street with my bike. First riding Palomar Mtn. here in San Diego. I lowsided at 70mph, managing only to scrape up the handguard, sliders and Fastway footpeg on that side. The bike slid in front of me for a distance before the tires made contact with a curb, then highsiding the bike. After that, it was just a loose zerk fitting on the front brakes. I was able to ride it pretty gingerly home after that.
Another time on the freeway during morning commute. I was spitting lanes when the traffic ahead came to a screeching halt for what turned out to be another bike accident further ahead. Three cars pulled out from the left to get into the right lane all at once just in front of me, and with cars to both my right and left and no time to brake, I needed to split-second maneuver around these people. I got around the first two with hard right/hard left switchovers once they saw me coming and stayed put in the center. The third guy kept moving over though, and the person behind him started getting over at that point also making a left hand maneuver more dangerous. Went sideways right and left to get around him and by that time traffic was completely stopped with the smallest opening between two cars in front of me. I went for it, still at speed, and ended up clipping the tail section on a Ridgeline, which sent me sliding right into a Grand Prix. I flew over the handlebars landing on my back and helmet. I laid there about 30sec assessing my arm/leg/neck movements before getting up to walk over and pick up the bike. The damage was a handguard, the peg (again), the DRC tail light getting bent down in it's bracket and a destroyed license plate. Aside from that, the bike started right up and after some fiddling and bending, was good to ride.
I didn't incur any injuries from either crash by wearing proper riding gear each time. Shoei helmet, Alpinestars leather jacket with upgraded back and chest armor, Forcefield padded pants and Kevlar jeans, SMX-5 boots, Rev'It! leather gloves. ATGATT... I'm definitely a believer.