I think it would change the tone and maybe the dB output slightly, but nothing dramatic in my experience as I've used FMF Q4 mufflers with both of those headers, one on a WR-250R and one on a WR-250X.
I also believe that if a rider feels the Q4 is too loud, just go back to the stock muffler because I know of no quieter aftermarket muffler.
Actually, when I eventually sold my 2008 WR-250R with the Q4 and Powerbomb header and the guy who came up to see and test ride the bike was pulling out of the driveway and then headed down the road, I remember thinking to myself how reasonable the exhaust noise output was.