yes - you will need a longer chain to go from 13/43 to 13/48.
On my wr250x I needed 112 links. The stock chain was 108 links.
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2008 WR250X
Gearing: 13t - 48t
Power Commander 5 / PC-V
Airbox Door Removed - Flapper glued - AIS removed
FmF Q4
Bridgestone Battlax BT-003rs